- Title
- Docosapentaenoic acid (22:5n-3): a review of its biological effects
- Creator
- Kaur, Gunveen; Cameron-Smith, David; Garg, Manohar; Sinclair, Andrew J.
- Relation
- Progress in Lipid Research Vol. 50, Issue 1, p. 28-34
- Publisher Link
- http://dx.doi.org/10.1016/j.plipres.2010.07.004
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2011
- Description
- This article summarizes the current knowledge available on metabolism and the biological effects of n-3 docosapentaenoic acid (DPA). n-3 DPA has not been extensively studied because of the limited availability of the pure compound. n-3 DPA is an elongated metabolite of EPA and is an intermediary product between EPA and DHA. The literature on n-3 DPA is limited, however the available data suggests it has beneficial health effects. In vitro n-3 DPA is retro-converted back to EPA, however it does not appear to be readily metabolised to DHA. In vivo studies have shown limited conversion of n-3 DPA to DHA, mainly in liver, but in addition retro-conversion to EPA is evident in a number of tissues. n-3 DPA can be metabolised by lipoxygenase, in platelets, to form ll-hydroxy-7,9,13,16,19- and 14-hydroxy-7,10,12,16,19-DPA. It has also been reported that n-3 DPA is effective (more so than EPA and DHA) in inhibition of aggregation in platelets obtained from rabbit blood. In addition, there is evidence that n-3 DPA possesses 10-fold greater endothelial cell migration ability than EPA, which is important in wound-healing processes. An in vivo study has reported that n-3 DPA reduces the fatty acid synthase and malic enzyme activity levels in n-3 DPA-supplemented mice and these effects were stronger than the EPA-supplemented mice. Another recent in vivo study has reported that n-3 DPA may have a role in attenuating age-related decrease in spatial learning and long-term potentiation. However, more research remains to be done to further investigate the biological effects of this n-3 VLCPUFA.
- Subject
- n-3 polyunsaturated fatty acids (VLCPUFA); eicosapentaenoic acid (EPA); docosapentaenoic acid (DPA); docosahexaenoic acid (DHA)
- Identifier
- http://hdl.handle.net/1959.13/1065230
- Identifier
- uon:17785
- Identifier
- ISSN:0163-7827
- Language
- eng
- Reviewed
- Hits: 4073
- Visitors: 3463
- Downloads: 282
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Author final version | 458 KB | Adobe Acrobat PDF | View Details Download |